4/1/03-3/31/04

Scott Sieg,  Ph.D., Division of Infectious Diseases

Relationship between CD4+ T cell proliferation function and immune responses to vaccination in HIV-infected patients

Christina  Hirsch, M.D., Ph.D., Division of Infectious Diseases

CD4 cell apoptosis and T cell responses in HIV/TB

Koh Fujinaga,  Ph.D., Division of Infectious Diseases

Establishment of an efficient screening method for inhibitors of HIV  transcription

4/1/02-3/31/03

Miguel Quinones, Ph.D.

Lethal mutagenesis as a new antiretroviral strategy

David  Cannaday, M.D.

Effects of HIV-1 on MHC-II antigent processing in monocytes

Don Anthony, M.D., Ph.D.

Characterization of Tcell immunity in HIV long-term non-progressors in viral infections and  to vaccine administered antigenic challenge.

Michael Cho, Ph.D.

Developing HIV-1 vaccine using recombinant parainfluenze virus.

4/1/01-3/31/02

Janet McGrath, Ph.D

Feasibility of clinical trials of vaginal microbicides for the prevention of HIV infection in Kampala, Uganda

Miguel Quinones, Ph.D.

Clinical relevance of HIV-1 superinfection on treatment failure

Lakshmi Ramachandra, Ph.D.

Role of MTB  phagosomes in the generation of peptide:  MHC-I complexes by the alternate MHC-I pathway

Alan Tartakoff, Ph.D.

RNA Specificity  of the essential HIV-1 Co-Factor, eIF-5A

Hernan Valdez, M.D.

Virologic  consequences of two supervised treatment interruptions in patients with chronic HIV infection and strong lymphoproliferative responses to an  HIV-gag antigen

Shwu-Yuan Wu,  Ph.D.

Transcriptional  regulation mediated by HIV Tat protein

4/1/00-3/31/01

Philip Garner, Ph.D., Department of Chemistry

The development  of novel PNSs for antisense AIDS therapeutics

Scot C.  Remick, M.D., Department of Hematology/Oncology

Dose-modified  oral chemotherapy in African AIDS-related lymphoma: A pilot study

Rolf Renne,  Ph.D., Department of Hematology/Oncology

Susceptibility of BM-derived cells to KSHV & their infection status in AIDS-Related KS

Robert Salata, M.D., Division of Infectious Diseases

HPV infections in women attending the National Sexually Transmitted Disease (STD) Referral Centre in Uganda: Prevalence, genotypes, and relationships to HIV infection, other STDs, and cervical intraepithelial lesions

Charles R. Sanders, Ph.D., Department of Physiology & Biophysics

Structural studies of the CCR5 chemokine receptor

Richard  Silver, M.D., Divisions of Pulmonary & Critical Care Medicine & Infectious Diseases

Pulmonary immune responses to mycobacterium tuberculosis

4/1/99-3/31/00

Irene Lee, Ph.D., Department of Chemistry

Molecular mechanisms of AZT  resistance by human immunodeficiency virus type 1 reverse  transcriptase

Janet W. McGrath, M.D., Department of Chemistry

Follow-up of HIV serodiscordant couples in Uganda

4/1/98-3/31/99

Mahmoud A. Ghannoum, Ph.D., Center for Medical Mycology, Department of  Dermatology

Development of DNA-based immunotherapy for candidiasis

John J.  Mieyal, Ph.D., Department of Pharmacology

Role of  Thioltransferase in regulation of HIV-1 protease activity and viral  infection.

4/1/97-3/31/98

Philip Garner, Ph.D., Department of Chemistry

Development of Novel Peptide Nucleic Acids ad Antisense and Antigene Agents

Eric Arts, Ph.D., Division of Infectious Diseases

Deciphering the  mechanisms responsible for nucleoside analog (e.g. AZT) resistance by HIV-1 variants and HIV-1 heterogeneity, recombination and pathogenesis interaction of the HIV tat protein with the dsRNA active protein kinase,  PKR.

4/1/96-3/31/97

P. Rather, Ph.D., Department of Medicine & P. de Haseth, Ph.D., Department of  Biochemistry

Development of a high-level regulated expression system in Mycobacteria

P. Lehmann,  M.D., Ph.D., Department of Pathology

Use of the ELISA spot to monitor human CD4 and CD8 cell responses to HIV  peptides

P.Toltzis, M.D., Department  of Pediatrics

HIV-1 phenotype  and disease progression in perinatally infected children reaching adolescence

G. Klopman, Ph.D., Department of Chemistry

Computer-aided drug design of new anti-mycobacterium tuberculosis quinolones

H.J. Kung, Ph.D., Department of Molecular Biology & C.Z. Giam, Ph.D., Dept. of Medicine

Isolation and  chracterizations of Kaposi-Sarcoma cells

J.J. Ellner, M.D., Department of Infectious Diseases

Development of a CTL laboratory in Uganda

M. Lederman, M.D., Department of Infectious Diseases

Improvements of ACTU/SID facilities

AM.  Mandalakas, M.D., Department of Pediatrics

Use of Mantoux testing in children who have received BCG vaccination – Uganda

4/1/95-3/31/96

Susan  Eshleman, M.D., Ph.D., Department of Pathology

Vertical HIV transmission in Uganda: analysis of amino acid sequences and glycosylation patterns of the V3 region of gpl20.

Sanjay Pimplikar, Ph.D., Department of Pathology

Mechanism of HIV entry across the mucosal barrier. 

Bryan  Williams, Ph.D., Department of Cancer Biology, Cleveland Clinic  Foundation

Interaction of the HIV tat protein with the dsRNA active protein kinase, PKR

P.R. Carey, Ph.D., Department of Biochemistry

Analyzing  interactions between drug candidates and HIV enzymes by Raman Spectroscopy

4/1/94-3/31/95

W. Henry Boom, M.D., Division of Infectious Diseases

Activation and function of gamma delta T cells in HIV infected individuals.

Debra  Leonard, M.D., Ph.D., Department of Pathology

Quantitative PCR for CMV DNA as a predictor for clinical relapse of CMV retinitis in AIDS  patients.

Chou-Zen Giam, Ph.D., Department of Medicine

Regulation of  Interleukin 12 expression in response to HIV  infection.        

David Kaplan,  M.D., Ph.D., Department ofPathology

ELISPOT  determination of cytokine secretion in HIV infected patients.